After Roglič's crash and eventual abandon, Vingegaard became the team's leader and rode into form in the second week. Vingegaard was originally supposed to be a domestique for his team's original leader, Primož Roglič. He won by 5' 20' over Jonas Vingegaard of Team Jumbo–Visma.

Pogačar rode defensively in the second week before winning both mountaintop finishes at Col de Portet and Luz Ardiden in the third week. He gained another half minute the next day on the summit finish to Tignes. He first took the maillot jaune on stage 8, when he gained almost three and a half minutes on the other contenders after attacking on the penultimate climb of the Col de Romme. Pogačar began to build his advantage with his win in the stage 5 time trial. The race was won for the second consecutive year by Tadej Pogačar of UAE Team Emirates, becoming the youngest rider to win the Tour twice. Denmark instead hosted the Grand Départ in 2022. This would have been the first occasion on which the Tour de France had visited Denmark.

Originally scheduled for 2 to 25 July 2021, the Tour was moved to 26 June to 18 July 2021 to avoid the rescheduled 2020 Summer Olympics. Originally planned for the Danish capital of Copenhagen, the start of the 2021 Tour (known as the Grand Départ) was transferred to Brest because of the COVID-19 pandemic, with Copenhagen hosting four matches in the UEFA Euro 2020, which had also been rescheduled to 2021 because of the pandemic. The 2021 Tour de France was the 108th edition of the Tour de France, one of cycling's three grand tours.

Die antwoord tour 2021 cancelled